2 Ocak 2013 Çarşamba

Antibiotic-Producing Bacteria Isolated From Honey, Bee Intestines

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Inhibitory Activity of Surfactin, Produced by Different Bacillussubtilis Subsp. subtilis Strains, Against Listeria Monocytogenes Sensitive and Bacteriocin-ResistantStrainsMicrobiol Res, 2012 Dec 19Three surfactin-producing Bacillus subtilis strains, C4, M1and G2III, previously isolated from honey and intestines from the Apismellifera L. bee, were phylogenetically characterized at sub-species level asB. subtilis subsp. subtilis using gyrA gene sequencing. The antagonistic effectof surfactin was studied against seven different Listeria monocytogenesstrains, 6 of which were resistant to bacteriocins. Surfactin showedanti-Listeria activity against all 7 strains and a dose of 0.125mg/mL ofsurfactin was enough to inhibit this pathogen. Surfactin sintetized by B.subtilis subsp. subtilis C4 inhibited the pathogen in lower concentrations,0.125mg/mL, followed by G2III and M1 with 0.25 and 1mg/mL, respectively. Inparticular, a dose of 0.125mg/mL reduced the viability of L. monocytogenes99/287 RB6, a bacteriocin-resistant strain, to 5 log orders. Surfactin assayedmaintained anti-Listeria activity within a pH range of between 2 and 10, afterheat treatment (boiling for 10min and autoclaving at 121°C for 15min) and aftertreatment with proteolytic enzymes. These results suggest that surfactin can beused as a new tool for prevention and the control of L. monocytogenes indifferent environments, for example, in the food industry.

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