Yeasts as Important Agents of Onychomycosis: In VitroActivity of Propolis Against Yeasts Isolated from Patients with Nail Infection The Journal of Alternative and Complementary MedicineObjective: The purposes of this study were to determine thefrequency of the yeast species obtained from patients with clinical features ofonychomycosis and the in vitro antifungal susceptibility of the yeast speciesto propolis.Methods: A prospective study was carried out at the MycologyResearch Center in Iran from 2010 to 2011. Clinical diagnosis was performed by directmicroscopic examination and culture. Different yeast species were identified bymorphological and biochemical tests. An antifungal susceptibility test tofluconazole (FLU) and propolis by the broth microdilution method was performedon each isolate.Results: One hundred and twenty-eight fungal isolates wereobtained. The most prevalent fungi were yeasts (81, 63.2%), dermatophytes (36,28.1%), and nondermatophyte fungi (11, 8.6%). Fingernails were more affectedthan toenails (65.4% vs. 19.8%, respectively). The most frequently foundspecies was Candida albicans (38.5%), followed by Candida spp. (23.1%), C.tropicalis (10.8%), C. kefyr (6.2%), C. krusei (3.1%), Malassezia globosa(4.6%), M. slooffiae (4.6%), and M. pachydermatis (1.5%). Of all yeast isolates(65), seven showed resistance to FLU. The average MIC of propolis forFLU-susceptible isolates was 5.8 μg/mL, whereas this value was 12.25 μg/mL forFLU-resistant isolates.Conclusion: Our results proved that the propolis inhibitsthe growth of pathogenic yeasts and confirmed the efficiency of propolis as ananti-Candida and anti-Malassezia agent.
21 Eylül 2012 Cuma
Propolis May Help Treat Nail Infections
Yeasts as Important Agents of Onychomycosis: In VitroActivity of Propolis Against Yeasts Isolated from Patients with Nail Infection The Journal of Alternative and Complementary MedicineObjective: The purposes of this study were to determine thefrequency of the yeast species obtained from patients with clinical features ofonychomycosis and the in vitro antifungal susceptibility of the yeast speciesto propolis.Methods: A prospective study was carried out at the MycologyResearch Center in Iran from 2010 to 2011. Clinical diagnosis was performed by directmicroscopic examination and culture. Different yeast species were identified bymorphological and biochemical tests. An antifungal susceptibility test tofluconazole (FLU) and propolis by the broth microdilution method was performedon each isolate.Results: One hundred and twenty-eight fungal isolates wereobtained. The most prevalent fungi were yeasts (81, 63.2%), dermatophytes (36,28.1%), and nondermatophyte fungi (11, 8.6%). Fingernails were more affectedthan toenails (65.4% vs. 19.8%, respectively). The most frequently foundspecies was Candida albicans (38.5%), followed by Candida spp. (23.1%), C.tropicalis (10.8%), C. kefyr (6.2%), C. krusei (3.1%), Malassezia globosa(4.6%), M. slooffiae (4.6%), and M. pachydermatis (1.5%). Of all yeast isolates(65), seven showed resistance to FLU. The average MIC of propolis forFLU-susceptible isolates was 5.8 μg/mL, whereas this value was 12.25 μg/mL forFLU-resistant isolates.Conclusion: Our results proved that the propolis inhibitsthe growth of pathogenic yeasts and confirmed the efficiency of propolis as ananti-Candida and anti-Malassezia agent.
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