Effect of Iranian Honey Bee (Apis mellifera) Venom on BloodGlucose and Insulin in Diabetic RatsJ Arthropod Borne Dis, 2012 Dec;6(2):136-43BACKGROUND: Diabetes is an important disease. This disease is ametabolic disorder characterized by hyperglycemia resulting from perturbationin insulin secretion, insulin action or both. Honey bee venom contains a widerange of polypeptide agents. The principle components of bee venom are mellitinand phospholipase A(2). These components increase insulin secretion from theβ-cells of pancreas. This study was conducted to show the hypoglycemic effectof honey bee venom on alloxan induced diabetic male rats.METHODS: Eighteen adult male rats weighting 200±20 g were placed into3 randomly groups: control, alloxan monohydrate-induced diabetic rat andtreated group that received honey bee venom daily before their nutrition forfour months. Forty eight hours after the last injection, blood was collectedfrom their heart, serum was dissented and blood glucose, insulin, triglycerideand total cholesterol were determined.RESULTS: Glucose serum, triglyceride and total cholesterol level intreated group in comparison with diabetic group was significantly decreased (P <0.01). On the other hand, using bee venom causes increase in insulin serum incomparison with diabetic group (P < 0.05).CONCLUSION: Honeybee venom (apitoxin) can be used as therapeutic optionto lower blood glucose and lipids in diabetic rats.
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