Oral Mucosal Adhesive Films Containing Royal JellyAccelerate Recovery From 5-Fluorouracil-Induced Oral MucositisJ Pharmacol Sci, 2013 Jan 25Oral mucositis induced by chemotherapy or radiotherapy hasan impact upon quality-of-life, is dose-limiting for chemotherapy, and causesconsiderable morbidity. We evaluated the effect of royal jelly (RJ) on5-fluorouracil (5-FU)-induced oral mucositis in hamsters. Oral mucositis was induced in hamsters through a combinationof 5-FU treatment and mild abrasion of the cheek pouch. RJ was contained inchitosan-sodium alginate film (RJ film). Films were attached to the oral mucosaand the healing process examined by measuring the area of mucositis,myeloperoxidase (MPO) activity, microscopic aspects, and RT-PCR for detectionof pro-inflammatory cytokines (tumor necrosis factor-α, interleukin-1β).Furthermore, we evaluated the radical-scavenging activity of RJ and generationof keratinocyte growth factor from human periodontal ligament fibroblasts. RJfilms (10%, 30%) significantly improved recovery from 5-FU-induced damage,reduced MPO activity and the production of pro-inflammatory cytokines.Additionally, RJ showed radical-scavenging activity. These data suggest that topical application of films thatcontain RJ had a healing effect on the severe oral mucositis induced by 5-FUand that the effect was caused by the anti-inflammatory or anti-oxidativeactivities of RJ.
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