Honey Based Gel a Good Alternative to Traditional Burn Wound Treatment

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The Effect of a Honey Based Gel and Silver Sulphadiazine on BacterialInfections of in vitro Burn WoundsBurns, 2012 Oct 1, pii: S0305-4179(12)00297-5Bacterial contamination remains a constant threat in burnwound care. Topical treatments to combat contaminations have good bactericidaleffects but can have detrimental effects for the healing process. Treatmentswith for example silver can increase healing times. Honey based products can be a good alternative as it isantibacterial and patient-friendly. We evaluated the bactericidal and cytotoxiceffects of a honey based gel and silver sulphadiazine in a human burn woundmodel with Pseudomonas aeruginosa. After adding 10(5)colony forming units of P. aeruginosa,topical treatments were applied on the burn wound models. After 2, 12, 24, 28and 70h, bacteria were dislodged and counted by plating dilutions. Cytotoxiceffects were evaluated histologically in samples of burn wound models treatedtopically for 3weeks, without bacteria. l-Mesitran Soft significantly reducedthe bacterial load (5-log reduction) up to 24h but did not completely eliminatebacteria from the burn wounds. After Flammazine(®) treatment, only a few colonyforming units were observed at all time points. In contrast,re-epithelialization was significantly reduced after application ofFlammazine(®) compared to l-Mesitran Soft or control. This in vitro model of burn wound infection can be used toevaluate topical treatments. l-Mesitran Soft is a good alternative.