An Initial Investigation into the Anti-Inflammatory Activityand Antioxidant Capacity of Alpha-Cyclodextrin-Complexed Manuka HoneyJ Complement Integr Med, 2012 Sep 24;9(1):Article 25The bioactive properties of Manuka honey are now wellrecognised, but the nature of honey (a sticky, viscous fluid) can make it hardto use as a health remedy. A new technology using encapsulation of Manuka honey withalpha-cyclodextrin molecules has been developed, creating a free-flowing powderthat can easily be added to foods and beverages, or tableted / made intocapsules for use in health. In this study, we investigated for antioxidant and anti-inflammatoryactivity. Antioxidant capacity of raw Manuka honeys and matched complexes wasmeasured using the CUPRAC method. Results showed that the antioxidant activity of honeydecreased when complexed, this being directly related to dilution of the final productwith alpha-cyclodextrin. Anti-inflammatory activity was assessed by measuringinhibition of neutrophil TNF-alpha secretion. Contradictory results wereproduced, with both stimulation and inhibition of TNF-alpha being observed. Data from this study indicate that the formation ofcyclodextrin-based complexes of Manuka honey may potentiate theanti-inflammatory activity of honey, but this may differ depending onmethylglyoxal content and the presence of other factors.
8 Ekim 2012 Pazartesi
Study Examines Anti-Inflammatory Activity, Antioxidant Capacity of ‘Complexed’ Manuka Honey
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An Initial Investigation into the Anti-Inflammatory Activityand Antioxidant Capacity of Alpha-Cyclodextrin-Complexed Manuka HoneyJ Complement Integr Med, 2012 Sep 24;9(1):Article 25The bioactive properties of Manuka honey are now wellrecognised, but the nature of honey (a sticky, viscous fluid) can make it hardto use as a health remedy. A new technology using encapsulation of Manuka honey withalpha-cyclodextrin molecules has been developed, creating a free-flowing powderthat can easily be added to foods and beverages, or tableted / made intocapsules for use in health. In this study, we investigated for antioxidant and anti-inflammatoryactivity. Antioxidant capacity of raw Manuka honeys and matched complexes wasmeasured using the CUPRAC method. Results showed that the antioxidant activity of honeydecreased when complexed, this being directly related to dilution of the final productwith alpha-cyclodextrin. Anti-inflammatory activity was assessed by measuringinhibition of neutrophil TNF-alpha secretion. Contradictory results wereproduced, with both stimulation and inhibition of TNF-alpha being observed. Data from this study indicate that the formation ofcyclodextrin-based complexes of Manuka honey may potentiate theanti-inflammatory activity of honey, but this may differ depending onmethylglyoxal content and the presence of other factors.
An Initial Investigation into the Anti-Inflammatory Activityand Antioxidant Capacity of Alpha-Cyclodextrin-Complexed Manuka HoneyJ Complement Integr Med, 2012 Sep 24;9(1):Article 25The bioactive properties of Manuka honey are now wellrecognised, but the nature of honey (a sticky, viscous fluid) can make it hardto use as a health remedy. A new technology using encapsulation of Manuka honey withalpha-cyclodextrin molecules has been developed, creating a free-flowing powderthat can easily be added to foods and beverages, or tableted / made intocapsules for use in health. In this study, we investigated for antioxidant and anti-inflammatoryactivity. Antioxidant capacity of raw Manuka honeys and matched complexes wasmeasured using the CUPRAC method. Results showed that the antioxidant activity of honeydecreased when complexed, this being directly related to dilution of the final productwith alpha-cyclodextrin. Anti-inflammatory activity was assessed by measuringinhibition of neutrophil TNF-alpha secretion. Contradictory results wereproduced, with both stimulation and inhibition of TNF-alpha being observed. Data from this study indicate that the formation ofcyclodextrin-based complexes of Manuka honey may potentiate theanti-inflammatory activity of honey, but this may differ depending onmethylglyoxal content and the presence of other factors.
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