Improving Antibiotic Activity against Wound Pathogens withManuka Honey In VitroPLoS ONE 7(9): Published on September 26, 2012Following the discovery of synergistic action betweenoxacillin and manuka honey against methicillin-resistant Staphylococcus aureus,this study was undertaken to search for further synergistic combinations ofantibiotics and honey that might have potential in treating wounds. Fifteen antibiotics were tested with and without sublethalconcentrations of manuka honey against each of MRSA and Pseudomonas aeruginosausing disc diffusion, broth dilution, E strip, chequerboard titration andgrowth curves. Five novel antibiotic and manuka honey combinations werefound that improved antibacterial effectiveness in vitro and these offer a newavenue of future topical treatments for wound infections caused by these twoimportant pathogens.
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