MS Timeline

To contact us Click HERE
Information provided to us from Maria Z., in Miami

1380St. Lidwina born in Holland; her progressive illnesssuggests a diagnosis of MS
1794Birth of Augustus d'Este, an early case of what wouldlater be known as MS
1838Robert Carswell includes an illustration of a case of"a peculiar disease state," showing the features of MS
1868Jean-Martin Charcot gives three lectures describing thefeatures of MS and names it "sclérose en plaque disseminée"
1873-1875A series of cases are published in London by WilliamMoxom
1884-1887Numerous lectures and published case reports; opticneuritis andmyelitis described (1884); infection suggested as a cause (1884);family with 12 cases of MS described (1885); toxins suggested as a cause (1887)
1891The lumbar puncture technique is developed
1899Oligodendrocytes (cells that produce and maintain myelin)are described
1906A toxin tomyelin is suggested for the breakdown of myelinin plaques
1915James Dawson publishes his major work on the pathology ofthe MS plaque
1933Animal model of MS (EAE) is developed; folding wheelchairinvented by Everest, allowing individuals with disabilities to travel by carand bring their wheelchair
1950Roy Swank develops lowfat diet for individuals with MS;first major study conducted in the US and Canada, funded by NMSS
1951First use of Cortisone to treat MS
1955Kutzke defines Disability Status Scale
1957Interferons are discovered
1965The initial criteria for diagnosis of MS is described
1968Thieme develops the electric mobility scooter
1970Acute MS flare-ups are treated with adrenocorticotropin
1972McDonald and Halliday show that conduction is slowed orblocked along demyelinated nerves and use evoked potential methods with MS
1977Jacobs gives interferon to MS patients intrathecally;McDonald and Halliday outline new diagnostic criteria for MS; oral baclofenapproved to treat spasticity
1978Patterns of myelin repair are demonstrated by Prineas
1980s-1990sTegretol® is used to treat pain; Ditropan® is used totreat spastic bladder; as with most symptom management drugs, these areprescribed off-label
1981First MRI scan of the brain is performed and first MRIimages of MS lesions produced; Jacobs reports reduced exacerbations withintrathecal interferon
1983Poser criteria described for MS; Epstein-Barr virussuspected of being involved with MS; Kurtzke introduces Expanded DisabilityStatus Scale (EDSS)
1987Prozac® is approved to treat depression; first SSRIantidepressant
1988Medtronic® Synchromed™ pump and infusion system(implanted and programmable) receives premarket approval
1990Americans with Disabilities Act signed into law
1990sAmantidine is used to treat fatigue
1993Betaseron® approved; Neurontin® approved to treat pain
1995Copaxone® approved
1996Avonex® approved
1998Provigil® approved to treat fatigue; Viagra® approved totreat sexual dysfunction
2000Novantrone® approved
2002Rebif® approved; Zanaflex® approved to treat spasticityin MS
2006Tysabri® approved
2010Extavia® approved; Gilenya™ approved; Botox® injectionapproved for adult upper-limb spasticity; Nuedexta™ approved for the treatmentof pseudobulbar affect (PBA); Ampyra™ approved to improve walking inindividuals with MS
2011Botox® injection approved for urinary incontinence inindividuals with MS
2012Aubagio® approved
THE FUTUREPossible approvals of Dimethyl Fumarate (DMF); Lemtrada™;ocrelizumab; daclizumab; Tovaxin®; laquinimod; and many more!

If you would like, you can comment to our blog posts LIKE this Blog by clicking the LIKE button - top left

 REMAIN up to date with MS News and Education

Visit: www.msviewsandnews.org  to register

.