Apimedica: Bee Venom Can Improve Heart Function - 蜂毒对心衰的治疗作用研究

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Oct. 22-25, 2012Zhenjiang, ChinaResearch on the Therapeutic Effect of Bee Venom on CardiacFailureLIU Jie, YANG Wen-chao, MIAO Xiao-qing*(Bee Science College of Fujian Agriculture and ForestryUniversity, State and Local Joint Engineering Laboratory of Natural Biotoxi,Fuzhou 350002,China )This study aims to explore the effect and the possibletherapeutic mechanism of whole bee venom on cardiac failure, in order toprovide the experimental evidence for the clinical application of bee venomanti-heart failure. Few researches have been done to discover the effect of beevenom in the treatment of heart disease at home and abroad. This experimentobserved the therapeutic effect of the venom solution of mice with heartfailure, and explored its functioning mechanism by measuring the physiologicalparameters of the heart. The results show that bee venom solution can improve theheart function of mice, alleviate the symptoms of cardiac failure. The extentof heart / body weight ratio decreases are: venom dose group (40%) > controlgroup (30%) > captopril group (28%) > venom high-dose bee venom group(14%) > low-dose bee venom group (9%). From the heart rate changes, high-dosebee venom group (319bpm) > captopril group (296 bpm)> control group (256bpm)> medium-to-low-dose bee venom group (240 bpm). B-type natriureticpeptide (BNP) assay shows that high-dose bee venom group (147.5pg/ml) >control group (130 pg/ml) > low-dose bee vonom group (80 pg/ml) >captopril group (75 pg/ml) > medium-dose bee vonom group (55 pg/ml). Insummary, the high-dose group (0.005mg/20g) can increase the heart rate in theshort term and is superior to the clinical treatment of heart failure drug,captopril.*Corresponding author, E-mail：mxqsf88@126.com蜂毒对心衰的治疗作用研究刘 å©•，æ�¨æ–‡è¶…，缪晓é�’*(ç¦�建农林大学蜂学学院，天然生物毒素国家地方è�”å�ˆå·¥ç¨‹å®žéªŒå®¤，ç¦�å·ž 350002，中国)本研究旨在探究全蜂毒对心è„�è¡°ç«­çš„å½±å“�å�Šå�¯èƒ½çš„作用机制，为临床应用蜂毒抗心衰æ��供实验ä¾�æ�®。ç›®å‰�国内外对于蜂毒在心è„�疾病方é�¢çš„治疗效果的研究较少，本实验主è¦�观察蜂毒水溶液对å°�白鼠心衰的治疗作用，并通过对心è„�å�„项生ç�†æŒ‡æ ‡çš„测定，探讨其作用机制。结果表明，蜂毒水溶液å�¯æ”¹å–„å°�鼠心功能，心衰的症状å‡�è½»，心è„�/体é‡�比值é™�低幅度为：蜂毒中剂é‡�组（40%）>对照组（30%）>å�¡æ‰˜æ™®åˆ©ç»„（28%）> 蜂毒高剂é‡�组（14%）>蜂毒低剂é‡�组（9%）。从心率å�˜åŒ–情况看，蜂毒低、中剂é‡�组（240bpm）＜对照组（256bpm）＜å�¡æ‰˜æ™®åˆ©ç»„（296 bpm）＜蜂毒高剂é‡�组（319bpm）。B 型尿钠肽（BNP）的测定结果显示，蜂毒中剂é‡�组55 pg/ml＜å�¡æ‰˜æ™®åˆ©ç»„75 pg/ml＜蜂毒低剂é‡�组80 pg/ml＜对照组130 pg/ml＜蜂毒高剂é‡�组 147.5pg/ml。综上所述，中剂é‡�组（0.003mg/20g）能有效抑制心率进程并优于临床心衰常用è�¯ç‰©å�¡æ‰˜æ™®åˆ©。关键è¯�: 蜂毒；心衰；心率；é…¶è�”å…�疫法