A Review of Molecular Mechanisms of the Anti-LeukemicEffects of Phenolic Compounds in HoneyInt J Mol Sci, 2012 Nov 15;13(11):15054-73Hematologic malignancies constitute about 9% of all newcases of cancers as reported via the GLOBOCAN series by International Agencyfor Research on Cancer (IARC) in 2008. So far, the conventional therapeutic andsurgical approaches to cancer therapy have not been able to curtail the risingincidence of cancers, including hematological malignancies, worldwide. The lastdecade has witnessed great research interest in biological activities ofphenolic compounds that include anticancer, anti-oxidation and anti-inflammation,among other things. A large number of anticancer agents combat cancer throughcell cycle arrest, induction of apoptosis and differentiation, as well asthrough inhibition of cell growth and proliferation, or a combination of two ormore of these mechanisms. Various phenolic compounds from different sourceshave been reported to be promising anticancer agents by acting through one ofthese mechanisms. Honey, which has a long history of human consumption bothfor medicinal and nutritional uses, contains a variety of phenolic compoundssuch as flavonoids, phenolic acids, coumarins and tannins. This paper presents a review on the molecular mechanisms ofthe anti-leukemic activity of various phenolic compounds on cell cycle, cellgrowth and proliferation and apoptosis, and it advocates that more studiesshould be conducted to determine the potential role of honey in bothchemoprevention and chemotherapy in leukemia.
12 Aralık 2012 Çarşamba
Honey May Help Prevent, Treat Leukemia
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A Review of Molecular Mechanisms of the Anti-LeukemicEffects of Phenolic Compounds in HoneyInt J Mol Sci, 2012 Nov 15;13(11):15054-73Hematologic malignancies constitute about 9% of all newcases of cancers as reported via the GLOBOCAN series by International Agencyfor Research on Cancer (IARC) in 2008. So far, the conventional therapeutic andsurgical approaches to cancer therapy have not been able to curtail the risingincidence of cancers, including hematological malignancies, worldwide. The lastdecade has witnessed great research interest in biological activities ofphenolic compounds that include anticancer, anti-oxidation and anti-inflammation,among other things. A large number of anticancer agents combat cancer throughcell cycle arrest, induction of apoptosis and differentiation, as well asthrough inhibition of cell growth and proliferation, or a combination of two ormore of these mechanisms. Various phenolic compounds from different sourceshave been reported to be promising anticancer agents by acting through one ofthese mechanisms. Honey, which has a long history of human consumption bothfor medicinal and nutritional uses, contains a variety of phenolic compoundssuch as flavonoids, phenolic acids, coumarins and tannins. This paper presents a review on the molecular mechanisms ofthe anti-leukemic activity of various phenolic compounds on cell cycle, cellgrowth and proliferation and apoptosis, and it advocates that more studiesshould be conducted to determine the potential role of honey in bothchemoprevention and chemotherapy in leukemia.
A Review of Molecular Mechanisms of the Anti-LeukemicEffects of Phenolic Compounds in HoneyInt J Mol Sci, 2012 Nov 15;13(11):15054-73Hematologic malignancies constitute about 9% of all newcases of cancers as reported via the GLOBOCAN series by International Agencyfor Research on Cancer (IARC) in 2008. So far, the conventional therapeutic andsurgical approaches to cancer therapy have not been able to curtail the risingincidence of cancers, including hematological malignancies, worldwide. The lastdecade has witnessed great research interest in biological activities ofphenolic compounds that include anticancer, anti-oxidation and anti-inflammation,among other things. A large number of anticancer agents combat cancer throughcell cycle arrest, induction of apoptosis and differentiation, as well asthrough inhibition of cell growth and proliferation, or a combination of two ormore of these mechanisms. Various phenolic compounds from different sourceshave been reported to be promising anticancer agents by acting through one ofthese mechanisms. Honey, which has a long history of human consumption bothfor medicinal and nutritional uses, contains a variety of phenolic compoundssuch as flavonoids, phenolic acids, coumarins and tannins. This paper presents a review on the molecular mechanisms ofthe anti-leukemic activity of various phenolic compounds on cell cycle, cellgrowth and proliferation and apoptosis, and it advocates that more studiesshould be conducted to determine the potential role of honey in bothchemoprevention and chemotherapy in leukemia.
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