Metabolic Effects of Honey in Type 1 Diabetes Mellitus: A RandomizedCrossover Pilot StudyJ Med Food, 2012 Dec 20The aim of this study was to evaluate the metabolic effectsof 12-week honey consumption on patients suffering from type 1 diabetesmellitus (DM). This was a randomized crossover clinical trial done in theNational Institute for Diabetes and Endocrinology, Cairo, Egypt. Twentypatients of both sexes aged 4-18 years with type 1 DM and HbA1C < 10%participated in the study. They were randomized into two equal groups (interventionto control and control to intervention). The dietary intervention was 12-weekhoney consumption in a dose of 0.5 mL/kg body weight per day. The main outcome measures were serum glucose, lipids, andC-peptide, and anthropometric measurements. None of participants were lost infollow-up. The intervention resulted in significant decreases in subscapularskin fold thickness, fasting serum glucose, totalcholesterol, serum triglycerides, and low-density lipoprotein, and significant increases in fasting C-peptide (FCP) and2-h postprandial C-peptide (PCP). As possible long-term effects ofhoney after its withdrawal, statistically significant reductions in midarmcircumference, triceps skin fold thickness, SSFT,FSG, 2-h postprandial serum glucose, TG, and HbA1C, and significant increases in FCP and PCP wereobserved. This small clinical trial suggests that long-termconsumption of honey might have positive effects on the metabolic derangementsof type 1 DM.
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