Systemic Benefits and Potential Uses of Tualang Honey in Additionto Its Beneficial Effects on Postmenopausal Bone Structure Clinics, vol.67 no.11 São Paulo Nov. 2012To the Editor,I read the recent article by Zaid et al. (1) with greatinterest. Recent research has shown that tualang honey may have a number ofsystemic benefits in addition to its protective effect on bone structure inpost-menopausal animal models.Tualang honey has considerable potential as an anti-canceragent. For example, it exerts anti-proliferative activities against breastcancer tissue, attenuating tumor growth in MDA-MB-231 and MCF-7 cell lines (2).These anti-neoplastic effects are mediated by caspase 2 and caspase 9activation and a reduction of the mitochondrial membrane potential in cancercells, reflecting an increase in apoptosis. Tualang honey administration alsoproduces early apoptosis in osteosarcomas in a dose-dependentmanner (3) andattenuates proliferation in HeLa cell lines (2). Apoptosis is also enhanced inoral squamous cell carcinomas following exposure to tualang honey (3).Furthermore, tualang honey reduces photo-carcinogenesissecondary to ultraviolet B radiation exposure (4). These anti-carcinogeniceffects are mediated by an attenuation of PGE-2 synthesis and inhibition of thenuclear translocation of NF-κB in keratinocytes. Methanol extracts of tualang honeyalso decrease proliferation in keloid fibroblasts and may thus be of clinicaluse in the dermatological treatment of keloids (5). Interestingly, gammaradiation enhances the anti-oxidant potential of tualang honey (6).Tualang honey is considered by some to be the naturalequivalent of "hormone replacement therapy". For example, short-termmemory is improved in post-menopausal women following the administration oftualang honey (7), which is comparable to the increase in short-term memory observedafter the administration of estrogen/progesterone combination therapy. Theadministration of tualang honey also attenuates atrophy in uterine tissue andincreases vaginal epithelium thickness (8). It is also associated with a lowerpost-menopausal increase in body weight.Tualang honey also decreases the wound size of burns andprovides enhanced control and containment of burn infections, especially bybacteria such as Pseudomonas aeruginosa (9). Tualang honey also exertsanti-oxidant activities against pancreatic cells, thus reducing hyperglycemiain diabetic models (10).The above examples clearly illustrate the various potentialuses of tualang honey and the need for further studies to fully elaborate theextent of its properties.
12 Aralık 2012 Çarşamba
Tualang Honey a Potential Anti-Cancer, Short-Term Memory Boosting Agent
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Systemic Benefits and Potential Uses of Tualang Honey in Additionto Its Beneficial Effects on Postmenopausal Bone Structure Clinics, vol.67 no.11 São Paulo Nov. 2012To the Editor,I read the recent article by Zaid et al. (1) with greatinterest. Recent research has shown that tualang honey may have a number ofsystemic benefits in addition to its protective effect on bone structure inpost-menopausal animal models.Tualang honey has considerable potential as an anti-canceragent. For example, it exerts anti-proliferative activities against breastcancer tissue, attenuating tumor growth in MDA-MB-231 and MCF-7 cell lines (2).These anti-neoplastic effects are mediated by caspase 2 and caspase 9activation and a reduction of the mitochondrial membrane potential in cancercells, reflecting an increase in apoptosis. Tualang honey administration alsoproduces early apoptosis in osteosarcomas in a dose-dependentmanner (3) andattenuates proliferation in HeLa cell lines (2). Apoptosis is also enhanced inoral squamous cell carcinomas following exposure to tualang honey (3).Furthermore, tualang honey reduces photo-carcinogenesissecondary to ultraviolet B radiation exposure (4). These anti-carcinogeniceffects are mediated by an attenuation of PGE-2 synthesis and inhibition of thenuclear translocation of NF-κB in keratinocytes. Methanol extracts of tualang honeyalso decrease proliferation in keloid fibroblasts and may thus be of clinicaluse in the dermatological treatment of keloids (5). Interestingly, gammaradiation enhances the anti-oxidant potential of tualang honey (6).Tualang honey is considered by some to be the naturalequivalent of "hormone replacement therapy". For example, short-termmemory is improved in post-menopausal women following the administration oftualang honey (7), which is comparable to the increase in short-term memory observedafter the administration of estrogen/progesterone combination therapy. Theadministration of tualang honey also attenuates atrophy in uterine tissue andincreases vaginal epithelium thickness (8). It is also associated with a lowerpost-menopausal increase in body weight.Tualang honey also decreases the wound size of burns andprovides enhanced control and containment of burn infections, especially bybacteria such as Pseudomonas aeruginosa (9). Tualang honey also exertsanti-oxidant activities against pancreatic cells, thus reducing hyperglycemiain diabetic models (10).The above examples clearly illustrate the various potentialuses of tualang honey and the need for further studies to fully elaborate theextent of its properties.
Systemic Benefits and Potential Uses of Tualang Honey in Additionto Its Beneficial Effects on Postmenopausal Bone Structure Clinics, vol.67 no.11 São Paulo Nov. 2012To the Editor,I read the recent article by Zaid et al. (1) with greatinterest. Recent research has shown that tualang honey may have a number ofsystemic benefits in addition to its protective effect on bone structure inpost-menopausal animal models.Tualang honey has considerable potential as an anti-canceragent. For example, it exerts anti-proliferative activities against breastcancer tissue, attenuating tumor growth in MDA-MB-231 and MCF-7 cell lines (2).These anti-neoplastic effects are mediated by caspase 2 and caspase 9activation and a reduction of the mitochondrial membrane potential in cancercells, reflecting an increase in apoptosis. Tualang honey administration alsoproduces early apoptosis in osteosarcomas in a dose-dependentmanner (3) andattenuates proliferation in HeLa cell lines (2). Apoptosis is also enhanced inoral squamous cell carcinomas following exposure to tualang honey (3).Furthermore, tualang honey reduces photo-carcinogenesissecondary to ultraviolet B radiation exposure (4). These anti-carcinogeniceffects are mediated by an attenuation of PGE-2 synthesis and inhibition of thenuclear translocation of NF-κB in keratinocytes. Methanol extracts of tualang honeyalso decrease proliferation in keloid fibroblasts and may thus be of clinicaluse in the dermatological treatment of keloids (5). Interestingly, gammaradiation enhances the anti-oxidant potential of tualang honey (6).Tualang honey is considered by some to be the naturalequivalent of "hormone replacement therapy". For example, short-termmemory is improved in post-menopausal women following the administration oftualang honey (7), which is comparable to the increase in short-term memory observedafter the administration of estrogen/progesterone combination therapy. Theadministration of tualang honey also attenuates atrophy in uterine tissue andincreases vaginal epithelium thickness (8). It is also associated with a lowerpost-menopausal increase in body weight.Tualang honey also decreases the wound size of burns andprovides enhanced control and containment of burn infections, especially bybacteria such as Pseudomonas aeruginosa (9). Tualang honey also exertsanti-oxidant activities against pancreatic cells, thus reducing hyperglycemiain diabetic models (10).The above examples clearly illustrate the various potentialuses of tualang honey and the need for further studies to fully elaborate theextent of its properties.
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