Cyprus University of Technology The palmar-plantar erythrodysesthesia (PPE) is the onlyclinical adverse event that commonly occurs with capecitabine and/or pegylatedliposomal doxorubicin treatment and it warrants special attention because it isthe most common dose-limiting toxicity. This study is designed to test theeffectiveness of a henna and propolis treatment protocol in the management ofcapecitabine and/or pegylated liposomal doxorubicin induced palmar-plantarerythrodysesthesia.
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