Effect of Royal Jelly on Spatial Learning and Memory in RatModel of Streptozotocin-Induced Sporadic Alzheimer's DiseaseAdv Biomed Res, 2012;1:26BACKGROUND: It has been recently demonstrated that Royal jelly (RJ) hasa beneficial role on neural functions. Alzheimer's disease (AD) is associatedwith impairments of learning and memory. Therefore, the present study wasdesigned to examine the effect of RJ on spatial learning and memory in ratsafter intracerebroventricular injection of streptozotocin (icv-STZ).MATERIALS AND METHODS: Rats were infused bilaterally with an icv injection of STZ,while sham rats received vehicle only. The rats were feed with RJ-containedfood (3% w/w) (lyophilized RJ mixed with powdered regular food) or regular foodfor 10 days. Then spatial learning and memory was tested in the rats by Morris watermaze test.RESULTS: Results showed that in icv-STZ group latency and path lengthwere increased as compared to sham group, also icv-STZ rats less remembered thetarget quadrant that previously the platform was located; however, these wereprotected significantly in STZ group that received RJ-containing food.
16 Aralık 2012 Pazar
Royal Jelly May Help Treat Alzheimer's Disease
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Effect of Royal Jelly on Spatial Learning and Memory in RatModel of Streptozotocin-Induced Sporadic Alzheimer's DiseaseAdv Biomed Res, 2012;1:26BACKGROUND: It has been recently demonstrated that Royal jelly (RJ) hasa beneficial role on neural functions. Alzheimer's disease (AD) is associatedwith impairments of learning and memory. Therefore, the present study wasdesigned to examine the effect of RJ on spatial learning and memory in ratsafter intracerebroventricular injection of streptozotocin (icv-STZ).MATERIALS AND METHODS: Rats were infused bilaterally with an icv injection of STZ,while sham rats received vehicle only. The rats were feed with RJ-containedfood (3% w/w) (lyophilized RJ mixed with powdered regular food) or regular foodfor 10 days. Then spatial learning and memory was tested in the rats by Morris watermaze test.RESULTS: Results showed that in icv-STZ group latency and path lengthwere increased as compared to sham group, also icv-STZ rats less remembered thetarget quadrant that previously the platform was located; however, these wereprotected significantly in STZ group that received RJ-containing food.
Effect of Royal Jelly on Spatial Learning and Memory in RatModel of Streptozotocin-Induced Sporadic Alzheimer's DiseaseAdv Biomed Res, 2012;1:26BACKGROUND: It has been recently demonstrated that Royal jelly (RJ) hasa beneficial role on neural functions. Alzheimer's disease (AD) is associatedwith impairments of learning and memory. Therefore, the present study wasdesigned to examine the effect of RJ on spatial learning and memory in ratsafter intracerebroventricular injection of streptozotocin (icv-STZ).MATERIALS AND METHODS: Rats were infused bilaterally with an icv injection of STZ,while sham rats received vehicle only. The rats were feed with RJ-containedfood (3% w/w) (lyophilized RJ mixed with powdered regular food) or regular foodfor 10 days. Then spatial learning and memory was tested in the rats by Morris watermaze test.RESULTS: Results showed that in icv-STZ group latency and path lengthwere increased as compared to sham group, also icv-STZ rats less remembered thetarget quadrant that previously the platform was located; however, these wereprotected significantly in STZ group that received RJ-containing food.
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