Anti-Inflammatory Activity of a Honey Flavonoid Extract on Lipopolysaccharide-ActivatedN13 Microglial CellsJ Agric Food Chem, 2012 Nov 26. [Epub ahead of print]Neuroinflammation is an important contributor topathogenesis of age-related neurodegenerative disorders as Alzheimer orParkinson´s disease. Accumulating evidence indicates that inhibition ofmicroglia-mediated neuroinflammation may become a reliable protective strategyfor neurodegenerative processes. Flavonoids, widely distributed in thevegetable kingdom and in aliments like honey have been suggested as noveltherapeutic agents for the reduction of the deleterious effects ofneuroinflammation. In the present study, we investigated the potentialprotective effect of a honey flavonoid extract (HFE) on the production ofproinflammatory mediators by lipopolysaccharide-stimulated N13 microglia. Ourresults show that HFE significantly inhibited the release of theproinflammatory cytokines as TNF-alpha and IL-1beta. The expressions of iNOSand the production of ROS were also significantly inhibited. Accordingly, present study demonstrates that HFE is a potentinhibitor of microglial activation and thus a potential preventive-therapeuticagent for neurodegenerative diseases involving neuroinflammation.
8 Aralık 2012 Cumartesi
Honey Flavonoid a Potential Preventive-Therapeutic Agent for Neurodegenerative Diseases
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Anti-Inflammatory Activity of a Honey Flavonoid Extract on Lipopolysaccharide-ActivatedN13 Microglial CellsJ Agric Food Chem, 2012 Nov 26. [Epub ahead of print]Neuroinflammation is an important contributor topathogenesis of age-related neurodegenerative disorders as Alzheimer orParkinson´s disease. Accumulating evidence indicates that inhibition ofmicroglia-mediated neuroinflammation may become a reliable protective strategyfor neurodegenerative processes. Flavonoids, widely distributed in thevegetable kingdom and in aliments like honey have been suggested as noveltherapeutic agents for the reduction of the deleterious effects ofneuroinflammation. In the present study, we investigated the potentialprotective effect of a honey flavonoid extract (HFE) on the production ofproinflammatory mediators by lipopolysaccharide-stimulated N13 microglia. Ourresults show that HFE significantly inhibited the release of theproinflammatory cytokines as TNF-alpha and IL-1beta. The expressions of iNOSand the production of ROS were also significantly inhibited. Accordingly, present study demonstrates that HFE is a potentinhibitor of microglial activation and thus a potential preventive-therapeuticagent for neurodegenerative diseases involving neuroinflammation.
Anti-Inflammatory Activity of a Honey Flavonoid Extract on Lipopolysaccharide-ActivatedN13 Microglial CellsJ Agric Food Chem, 2012 Nov 26. [Epub ahead of print]Neuroinflammation is an important contributor topathogenesis of age-related neurodegenerative disorders as Alzheimer orParkinson´s disease. Accumulating evidence indicates that inhibition ofmicroglia-mediated neuroinflammation may become a reliable protective strategyfor neurodegenerative processes. Flavonoids, widely distributed in thevegetable kingdom and in aliments like honey have been suggested as noveltherapeutic agents for the reduction of the deleterious effects ofneuroinflammation. In the present study, we investigated the potentialprotective effect of a honey flavonoid extract (HFE) on the production ofproinflammatory mediators by lipopolysaccharide-stimulated N13 microglia. Ourresults show that HFE significantly inhibited the release of theproinflammatory cytokines as TNF-alpha and IL-1beta. The expressions of iNOSand the production of ROS were also significantly inhibited. Accordingly, present study demonstrates that HFE is a potentinhibitor of microglial activation and thus a potential preventive-therapeuticagent for neurodegenerative diseases involving neuroinflammation.
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