Detection and Quantification of Pyrrolizidine Alkaloids inAntibacterial Medical HoneysPlanta Med, 2012 Nov 16In recent years, there has been an increasing interest inantibacterial honey for wound care ranging from minor abrasions and burns toleg ulcers and surgical wounds. On the other hand, several recent studiesdemonstrated that honey for human consumption was contaminated with naturaloccurring, plant derived pyrrolizidine alkaloids.1,2-Unsaturated pyrrolizidine alkaloids are a group ofsecondary plant metabolites that show developmental, hepato-, and geno-toxicityas well as carcinogenic effects in animal models and in in vitro test systems.Hence, it was of particular interest to analyze the pyrrolizidine alkaloidcontent of medical honeys intended for wound care.19 different medical honey samples and/or batches wereanalyzed by applying a recently established pyrrolizidine alkaloid sumparameter method. 1,2-Unsaturated pyrrolizidine alkaloids were converted intothe common necin backbone structures and were analyzed and quantified by GC-MSin the selected ion monitoring mode.All but one medical honey analyzed were pyrrolizidinealkaloid positive. The results ranged from 10.6 µg retronecine equivalents perkg to 494.5 µg retronecine equivalents/kg medical honey. The averagepyrrolizidine alkaloid content of all positive samples was 83.6 µg retronecineequivalents/kg medical honey (average of all samples was 79.3 µg retronecineequivalents/kg medical honey). The limit of detection was 2.0 µg retronecineequivalents/kg medical honey, while the limit of quantification was 6.0 µgretronecine equivalents/kg medical honey (S/N > 7/1).Based on the data presented here and considering the factthat medical honeys can be applied to open wounds, it seems reasonable todiscuss the monitoring of 1,2-unsaturated pyrrolizidine alkaloids in honeyintended for wound treatment.
28 Kasım 2012 Çarşamba
Antibacterial Medical Honeys Should Be Monitored for Pyrrolizidine Alkaloids
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Detection and Quantification of Pyrrolizidine Alkaloids inAntibacterial Medical HoneysPlanta Med, 2012 Nov 16In recent years, there has been an increasing interest inantibacterial honey for wound care ranging from minor abrasions and burns toleg ulcers and surgical wounds. On the other hand, several recent studiesdemonstrated that honey for human consumption was contaminated with naturaloccurring, plant derived pyrrolizidine alkaloids.1,2-Unsaturated pyrrolizidine alkaloids are a group ofsecondary plant metabolites that show developmental, hepato-, and geno-toxicityas well as carcinogenic effects in animal models and in in vitro test systems.Hence, it was of particular interest to analyze the pyrrolizidine alkaloidcontent of medical honeys intended for wound care.19 different medical honey samples and/or batches wereanalyzed by applying a recently established pyrrolizidine alkaloid sumparameter method. 1,2-Unsaturated pyrrolizidine alkaloids were converted intothe common necin backbone structures and were analyzed and quantified by GC-MSin the selected ion monitoring mode.All but one medical honey analyzed were pyrrolizidinealkaloid positive. The results ranged from 10.6 µg retronecine equivalents perkg to 494.5 µg retronecine equivalents/kg medical honey. The averagepyrrolizidine alkaloid content of all positive samples was 83.6 µg retronecineequivalents/kg medical honey (average of all samples was 79.3 µg retronecineequivalents/kg medical honey). The limit of detection was 2.0 µg retronecineequivalents/kg medical honey, while the limit of quantification was 6.0 µgretronecine equivalents/kg medical honey (S/N > 7/1).Based on the data presented here and considering the factthat medical honeys can be applied to open wounds, it seems reasonable todiscuss the monitoring of 1,2-unsaturated pyrrolizidine alkaloids in honeyintended for wound treatment.
Detection and Quantification of Pyrrolizidine Alkaloids inAntibacterial Medical HoneysPlanta Med, 2012 Nov 16In recent years, there has been an increasing interest inantibacterial honey for wound care ranging from minor abrasions and burns toleg ulcers and surgical wounds. On the other hand, several recent studiesdemonstrated that honey for human consumption was contaminated with naturaloccurring, plant derived pyrrolizidine alkaloids.1,2-Unsaturated pyrrolizidine alkaloids are a group ofsecondary plant metabolites that show developmental, hepato-, and geno-toxicityas well as carcinogenic effects in animal models and in in vitro test systems.Hence, it was of particular interest to analyze the pyrrolizidine alkaloidcontent of medical honeys intended for wound care.19 different medical honey samples and/or batches wereanalyzed by applying a recently established pyrrolizidine alkaloid sumparameter method. 1,2-Unsaturated pyrrolizidine alkaloids were converted intothe common necin backbone structures and were analyzed and quantified by GC-MSin the selected ion monitoring mode.All but one medical honey analyzed were pyrrolizidinealkaloid positive. The results ranged from 10.6 µg retronecine equivalents perkg to 494.5 µg retronecine equivalents/kg medical honey. The averagepyrrolizidine alkaloid content of all positive samples was 83.6 µg retronecineequivalents/kg medical honey (average of all samples was 79.3 µg retronecineequivalents/kg medical honey). The limit of detection was 2.0 µg retronecineequivalents/kg medical honey, while the limit of quantification was 6.0 µgretronecine equivalents/kg medical honey (S/N > 7/1).Based on the data presented here and considering the factthat medical honeys can be applied to open wounds, it seems reasonable todiscuss the monitoring of 1,2-unsaturated pyrrolizidine alkaloids in honeyintended for wound treatment.
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