Apimedica: Polyphenolic Content and Pharmacological Potential of French BFA Propolis Extracts - 法国BFA 蜂胶提取物的多酚类物质及药理作用潜能

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Apimondia Apimedica-ApiqualityInternational ForumOct. 22-25, 2012Zhenjiang, China Séverine BOISARD^a,Anne-Marie Le Ray^a, Julia Gatto^a, Marie-Christine Aumond^a,Anne Landreau^a, Marie Kempf^b, Isabelle Péruches^c,Catherine Flurin^c and Pascal Richomme^{a a}PRES LUNAM, Université d’Angers, EA 921SONAS, Angers, France, severine.boisard@etud.univ-angers.fr;^b CHU d’Angers, Laboratoire de Bactériologie, Angers, France; ^cBallot-FlurinApiculteurs, La miellerie, Lahitte-Toupière, France
Propolis, or bee glue, is a naturalresinous hive product collected by honeybees from buds and exudates of varioustrees and plants. Mixed with beewax and salivary enzymes, it is employed tofill cracks and embalm dead invaders in the hive. Propolis has been used infolk medecine since ancien times due to its pharmacological potentialassociated with antioxidant, antifungal, antibacterial as well as antitumoralproperties. A batch of various French propolis extracts, supplied by “Ballot-FlurinApiculteurs” (BFA), a company located in the South-West of France andspecialized in apitherapy products, was fractionated andanalysed by HPLC/MS. Its qualitative chemicalcomposition highlights the presence of polyphenols such as hydroxycinnamic acidderivatives and flavonoids. Total polyphenol content and antioxidant activitieswere evaluated on six BFA propolis extracts, using respectivelyFolin-Ciocalteu, DPPH and ORAC assays. Preliminary antifungal (Candida albicans) and antibacterial (Staphylococcus aureus) evaluations will alsobe given.
Key words: propolis, polyphenols, biological assays

法国BFA 蜂胶æ��å�–物的多酚类物质å�Šè�¯ç�†ä½œç”¨æ½œèƒ½Severine Boisard1, Anne-Marie Le Ray1, Julia Gatto1 , Marie-Christine Aumond1, Anne Landreau1, Marie Kempf2,Isabelle Peruches3, Catherine Flurin3, Pascal Richomme1 （法国）(1. Pres Lunam, Universited’Angers, EA 921 Sonas, Angers, France, ;2. Chu d’Angers,Laboratoire de Bacteriologie, Angers, France;3. Ballot-FlurinApiculteurs, La miellerie, Lahitte-Toupiere, France)蜂胶是一ç§�蜜蜂从多ç§�树木å�Šæ¤�物的嫩芽å�Šæ¸—出物中采集得到的天然树脂状蜂产å“�。å�Œèœ‚蜡和唾液酶混å�ˆ，蜜蜂将它用于填补蜂巢的ç¼�éš™å�ŠåŒ…裹入侵者的尸体。蜂胶具有良好的è�¯ç�†å­¦æ´»æ€§，包括抗氧化、抗 真è�Œ、抗细è�Œå�ŠæŠ—肿瘤活性等，故自å�¤ä»¥æ�¥å°±è¢«ç”¨äºŽæ°‘间医è�¯。我们对一批由Ballot-Flurin Apiculteurs（BFA）å…¬å�¸（ä½�于法国西å�—，专注于蜂疗产å“�çš„å¼€å�‘）æ��供的一批蜂胶æ��å�–物样å“�进行了分é¦�，并利用HPLC/MS 分æž�了其主è¦�æˆ�分。定é‡�分æž�结果表明BFA 蜂胶中富å�«å¤§é‡�的多酚类化å�ˆç‰©，如羟基肉桂酸è¡�生物、黄酮类化å�ˆç‰©ç­‰。我们主è¦�采用ç¦�林酚法、DPPH å’ŒORAC 法对六个BFA 蜂胶æ��å�–物的多元酚å�«é‡�å�Šå…¶æŠ—氧化 活性进行了研究。我们也åˆ�步评价了样å“�的抗真è�Œ（白色念ç� è�Œ）、抗细è�Œ（金黄色葡è�„ç�ƒè�Œ）的活性
关键è¯�：蜂胶；多酚类化å�ˆç‰©；生物学测定