Honey Component Has Anticancer Potential

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Anticarcinogenic Actions of Tributyrin, a Butyric AcidProdrugCurr Drug Targets, 2012 Nov 6Bioactive food compounds (BFCs) exhibit potentialanticarcinogenic effects that deserve to be explored. Butyric acid (BA) isconsidered a promising BFC and has been used in clinical trials; however, itsshort half-life considerably restricts its therapeutic application. Tributyrin (TB), a BA prodrug present in milk fat and honey,has more favorable pharmacokinetic properties than BA, and its oraladministration is also better tolerated. In vitro and in vivo studies haveshown that TB acts on multiple eanti-cancer cellular and molecular targets withoutaffecting non-cancerous cells. Among the TB mechanisms of action, the inductionof apoptosis and cell differentiation and the modulation of epigeneticmechanisms are notable. Due to its anticarcinogenic potential, strategies as lipidemulsions, nanoparticles, or structured lipids containing TB are currentlybeing developed to improve its organoleptic characteristics andbioavailability. In addition, TB has minimal toxicity, making it an excellentcandidate for combination therapy with other agents for the control of cancer.Despite the lack of data available in the literature, TB is a promisingmolecule for anticancer strategies. Therefore, additional preclinical andclinical studies should be performed using TB to elucidate its moleculartargets and anticarcinogenic potential.