Freeze-Dried Royal Jelly Maintains Its Developmental andPhysiological Bioactivity in Drosophila melanogasterBiosci Biotechnol Biochem, 2012 Nov 7Royal jelly (RJ), a honeybee-derived product, has been foundto possess developmental and physiological bioactivity in the fruit fly,Drosophila melanogaster, but little is known about the in vivo bioactivity offreeze-dried RJ (FDRJ) powder, which is another form of RJ processed for humanuse. To address this, we used Drosophila as a model animal to examine theeffects of FDRJ in multicellular organisms. When flies were reared on foodsupplemented with FDRJ, the developmental time from larva to adult wasshortened, the adult male lifespan was prolonged, and female fecundity wasincreased without any significant morphological alterations. Moreover, theexpression of dilp5, an insulin-like peptide, its receptor InR, and thenutrient sensing molecule TOR, the target of rapamycin, was significantlyincreased in FDRJ-fed female flies as compared with ones reared on standard andon protein-enriched food. These findings suggest that like RJ, FDRJ maintainsits bioactivity even after processing from RJ, what is expected to havebioactivity for multicellular organisms, including humans.
19 Kasım 2012 Pazartesi
Freeze-Dried Royal Jelly Maintains Bioactivity Even After Processing
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Freeze-Dried Royal Jelly Maintains Its Developmental andPhysiological Bioactivity in Drosophila melanogasterBiosci Biotechnol Biochem, 2012 Nov 7Royal jelly (RJ), a honeybee-derived product, has been foundto possess developmental and physiological bioactivity in the fruit fly,Drosophila melanogaster, but little is known about the in vivo bioactivity offreeze-dried RJ (FDRJ) powder, which is another form of RJ processed for humanuse. To address this, we used Drosophila as a model animal to examine theeffects of FDRJ in multicellular organisms. When flies were reared on foodsupplemented with FDRJ, the developmental time from larva to adult wasshortened, the adult male lifespan was prolonged, and female fecundity wasincreased without any significant morphological alterations. Moreover, theexpression of dilp5, an insulin-like peptide, its receptor InR, and thenutrient sensing molecule TOR, the target of rapamycin, was significantlyincreased in FDRJ-fed female flies as compared with ones reared on standard andon protein-enriched food. These findings suggest that like RJ, FDRJ maintainsits bioactivity even after processing from RJ, what is expected to havebioactivity for multicellular organisms, including humans.
Freeze-Dried Royal Jelly Maintains Its Developmental andPhysiological Bioactivity in Drosophila melanogasterBiosci Biotechnol Biochem, 2012 Nov 7Royal jelly (RJ), a honeybee-derived product, has been foundto possess developmental and physiological bioactivity in the fruit fly,Drosophila melanogaster, but little is known about the in vivo bioactivity offreeze-dried RJ (FDRJ) powder, which is another form of RJ processed for humanuse. To address this, we used Drosophila as a model animal to examine theeffects of FDRJ in multicellular organisms. When flies were reared on foodsupplemented with FDRJ, the developmental time from larva to adult wasshortened, the adult male lifespan was prolonged, and female fecundity wasincreased without any significant morphological alterations. Moreover, theexpression of dilp5, an insulin-like peptide, its receptor InR, and thenutrient sensing molecule TOR, the target of rapamycin, was significantlyincreased in FDRJ-fed female flies as compared with ones reared on standard andon protein-enriched food. These findings suggest that like RJ, FDRJ maintainsits bioactivity even after processing from RJ, what is expected to havebioactivity for multicellular organisms, including humans.
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